The efficacy of a single daily dose of enoxaparin for deep vein thrombosis prophylaxis following total knee arthroplasty.
نویسندگان
چکیده
Deep vein thrombosis (DVT) is a major risk following total knee arthroplasty (TKA). This prospective outcomes study evaluates the efficacy of enoxaparin 40 mg once daily for 7 days after TKA, by documenting symptomatic and asymptomatic outcomes using bilateral lower extremity duplex ultrasound upon hospital discharge and on postoperative day 21 (+/-2). In 60 extremities, duplex ultrasound demonstrated a DVT prevalence of 16.7% (10) on the day of discharge and of 11.7% (7) on postoperative day 21. No new DVT or propagation of distal to proximal DVT were noted. For this small cohort, enoxaparin 40 mg daily demonstrates effective prophylaxis for DVT in TKA patients.
منابع مشابه
Comparison of the oral direct thrombin inhibitor ximelagatran with enoxaparin as prophylaxis against venous thromboembolism after total knee replacement: a phase 2 dose-finding study.
BACKGROUND Up to one third of patients who undergo total knee replacement develop deep vein thrombosis after surgery despite receiving low-molecular-weight heparin prophylaxis. Ximelagatran is a novel direct inhibitor of free and clot-bound thrombin. METHODS We performed a randomized, parallel, dose-finding study of 600 adults undergoing elective total knee replacement at 68 North American ho...
متن کاملDalteparin vs. enoxaparin as prophylaxis for deep-vein thrombosis after total hip or knee arthroplasty: a retrospective analysis.
OBJECTIVE To assess the clinical and economic consequences of a formulary switch from enoxaparin to dalteparin as first-line prophylaxis for deep-vein thrombosis in patients undergoing inpatient rehabilitation after total hip arthroplasty or total knee arthroplasty. DESIGN Retrospective cohort study. RESULTS There were 461 patients eligible for the study. The age-adjusted risk of a deep-vei...
متن کاملA cost analysis of fondaparinux versus enoxaparin in total knee arthroplasty.
Several hundred thousand total knee replacement (TKR) surgeries are performed in the United States each year. The American College of Chest Physicians has classified TKR patients in the "highest-risk" category for developing venous thromboembolic events. Recommended prophylactic agents following TKR surgery include unfractionated heparin and low-molecular weight heparins. Fondaparinux is a sele...
متن کاملProphylaxis of DVT with enoxaparin in patients undergoing total knee replacement.
OBJECTIVE To evaluate the efficacy and safety of the low molecular weight heparin as prophylaxis against thromboembolism following total knee replacement surgery. METHODS Post-operative bilateral lower extremity colour duplex scan was performed on 55 patients subjected to total knew arthroplasty. The scan was performed 7 days after surgery for detection of DVT. All patients were given Enoxapa...
متن کاملPrevention of deep-vein thrombosis after total hip and knee replacement. Low-molecular-weight heparin in combination with intermittent pneumatic compression.
After total hip (THR) or knee replacement (TKR), there is still an appreciable risk of developing deep-vein thrombosis despite prophylaxis with low-molecular-weight heparin (LMWH). In a prospective, randomised study we examined the efficacy of LMWH in combination with intermittent pneumatic compression in patients undergoing primary unilateral THR or TKR. We administered 40 mg of enoxaparin dai...
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عنوان ژورنال:
- Orthopedics
دوره 27 11 شماره
صفحات -
تاریخ انتشار 2004